Types and Preparation of Liposomal Formulations for Pulmonary Administration

Authors

  • H. Hořavová Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno
  • J. Gadziok Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno
  • D. Vetchý Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno

Keywords:

liposomes, lung application, spray drying, lyophylization, dry powder formulations, protectants

Abstract

The use of liposomes as carriers for different types of drugs in formulations to be administered to the lungs brings a number of advantages, including the possibility of controlled release, prolongation of retention at the site of action or reduced systemic exposure. However, the main disadvantage of liposomal suspensions is their physical and chemical instability. Therefore, they are preferably converted to dry powders by several drying technologies. In doing so, it is necessary to include specific excipients in the formulation, in particular protectants (saccharides), protecting liposomes from changes during these processes.

Published

2020-05-15

How to Cite

Hořavová, H., Gadziok, J., & Vetchý, D. (2020). Types and Preparation of Liposomal Formulations for Pulmonary Administration. Chemické Listy, 114(5), 322–328. Retrieved from http://www-.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3599

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